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Every outbound email is checked against your do-not-contact list right before it sends. Names reach it automatically from opt-outs and bounces, or you add them yourself in Settings.
A settings page listing blocked email addresses and domains, each with a source such as added manually or opt-out reply, next to a paste box and an Add to list button.

The do-not-contact list, in Settings.

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Add and remove people yourself

1

Open Do not contact in Settings

Paste addresses or domains, one per line or separated by commas.
2

Click Add to list

An entry with no @ sign blocks a whole domain instead of one address.
3

Select rows and click Remove to undo it

That lets Oneprofile email them again. It never happens on its own.

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Let names reach the list automatically

An opt-out reply or a click on a sequence’s unsubscribe link adds the address automatically, and stops every sequence it was enrolled in. A hard-bounced address is blocked workspace wide, since a bounce proves the address does not exist. The inbox’s Do not contact action on a thread does the same.

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Export the list

Click Export to download the whole list as plain text, one value per line, ready to paste into another tool.

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Good to know

No. Removing only lets future emails reach them again. It does not re-enroll them in anything they were stopped from.
Blocking someone from the inbox shows which active sequences it stops before you confirm. The Settings list itself does not show a per-row impact preview.
Yes. Adding a value with no @ sign blocks every address on that domain, not just the one you had in mind.

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Next steps

Inbox

Read replies and apply the do-not-contact action from a thread.

Build a sequence

Add an opt-out footer while you build a sequence.